The toughest opponent that they will play in the out-of-conference schedule will be against the Alabama Crimson Tide. However, they will play in the Coaches vs. Cancer, which could provide a tough matchup.
When a team plays in a conference like the Big 12 it really does not have to have the toughest non-conference schedule. If that is in fact the case, the team will have to at least get one or two big wins in conference play to make the NCAA tournament (so many other factors go into it as well). The infamous resume is always a big deal and that is especially true in college hoops.
So in the Sooners’ case, beating Alabama would be a pretty solid win, but they will more than likely have to beat one of the top teams in the Big 12. A victory against Oklahoma State or Kansas would be huge, but who knows if that will happen.
There is a chance that Oklahoma will have to play Michigan State this year. The Spartans should be ranked in the top five to start the season, so that will clearly be a challenge for the Sooners.
Oklahoma did make the dance last season as a No. 10 seed. With such a weak non-conference schedule it will probably have to do work in the Big 12 to make the tourney once again. However, finishing in the top five of the conference standings is definitely not out of the question for this team–tied for fourth last season.