After the season-ending injury to Dion Lewis, James White will have a bigger role for the Patriots.
San Francisco 49ers RB Reggie Bush has hired a lawyer, and is reportedly planning on suing the City of St. Louis for his season-ending injury.
Veteran WR Steve Smith Sr. is out for the remainder of the season after tearing an Achilles against San Diego.
Although he hasn't practiced all week, Odell Beckham Jr. looks to have a decent chance at playing on MNF thanks to some positive developments.
Tennessee Titans QB Marcus Mariota suffered an apparent knee injury after taking a low hit from Olivier Vernon.
After losing Ben Roethlisberger to a knee injury earlier in the season, the Pittsburgh Steelers have now lost Michael Vick to a hamstring injury.
Kansas City Chiefs' Jamaal Charles suffered a knee injury on Sunday against the Chicago Bears that could be season-ending.
Seattle Seahawks RB Marshawn Lynch has been ruled out of Week 5 action, which essentially guarantees Seattle will lose to Cincinnati.
The Chicago Bears are banged up offensively, but Jay Cutler will take the field despite his ailment for a desperate football team.
With the official injury reports out, several key players are injured for the New York Giants and Buffalo Bills, which will have a huge impact on how the game plays out.