The San Francisco 49ers have lost a lot of players over the past couple of seasons, and are now in rebuild mode. They have a new coach, and hope to field a more competitive team. Here are five big games on their schedule in the upcoming season.
![5 Biggest Games On San Francisco 49ers\' 2016 NFL Schedule](/nfl/files/2016/04/49ers-320x180.jpg)
5. Los Angeles Rams – September 12
![Los Angeles Rams – September 12](/nfl/files/2016/04/Los-Angeles-Rams-1.jpg)
5. Los Angeles Rams – September 12
The Niners open against the Rams and this will be a tough division game against an opponent looking to make it to the postseason. The Rams have a very good defense and a young quarterback, and the Niners will want to start off the season strong.
4. Arizona Cardinals – October 6
![Arizona Cardinals – October 6](/nfl/files/2016/04/Arizona-Cardinals-1.jpg)
4. Arizona Cardinals – October 6
The Cardinals were one of the best teams in the conference last season, and the Niners will hope to play well against a division rival.
3. Carolina Panthers – September 18
![Carolina Panthers – September 18](/nfl/files/2016/04/Panthers-4.jpg)
3. Carolina Panthers – September 18
It will be interesting to see how Chip Kelly’s offense fares against one of the best defenses in the league. The Panthers have a lot of speed, and should be a good measuring stick for the Niners’ offense.
2. Los Angeles Rams – December 24
![Los Angeles Rams – December 24](/nfl/files/2016/04/Rams.jpg)
2. Los Angeles Rams – December 24
The Niners might be out of the playoff picture by this date, but there is a chance that this could be a meaningful divisional game.
1. Seattle Seahawks – January 1
![Seattle Seahawks – January 1](/nfl/files/2016/04/Seahawks-2-1.jpg)
1. Seattle Seahawks – January 1
This had recently become one of the best rivalries in football, although now it seems as if the Seahawks have the upper hand. The Niners would love the opportunity to spoil Seattle’s season.
![Share On Facebook](/nfl/wp-content/themes/rant-2017/library/images/facebook-white.png)
![StumbleUpon](/nfl/wp-content/themes/rant-2017/library/images/stumble-badge.png)